Optimizing CRISPR/Cas9 System to Precisely Model Plasminogen Activator Inhibitor-1 Point Mutations in Mice
Yang Liu, Thomas L. Saunders, Thomas H. Sisson, Robert Andrew Blackburn, David S. Ginsberg, Duane E. Day
This study optimizes CRISPR/Cas9 to model specific PAI-1 mutations in mice, finding that mutation distance from the DSB site affects editing efficiency.
bioRxiv · Jan 26, 2018 · PreprintGenetics