{triangleup}FOSB in the nucleus accumbens core is required for increased anxiety, but not decreased social motivation, following estrogen withdrawal in female mice
Willow Clayton, May Y. Courtney, Lilah E. Craig, Helen E. Moniz, Alison B. Gibbons, Alissa A. Valentine, Achint K. Singh, Dylan R. Gearinger, Eric J. Nestler, Laura E. Been
This study shows that increased {Delta}FOSB in the nucleus accumbens core during estrogen withdrawal in female mice is necessary for heightened anxiety but not reduced social motivation.
bioRxiv · Oct 21, 2025 · PreprintNeuroscience