PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca2+ mobilization irrespectively of its primary target
P. D. Kotova, E. A. Dymova, O. O. Lyamin, O. A. Rogachevskaja, S. S. Kolesnikov
This study shows that the PI3K inhibitor PI828 blocks Ca2+ responses to aminergic agonists through an unknown mechanism unrelated to PI3K inhibition, while wortmannin has minimal effect.
bioRxiv · Jan 17, 2024Pharmacology & Toxicology