Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain.
E. A. Gaviglio, J. M. Peralta Ramos, D. S. Arroyo, C. Bussi, P. Iribarren, M. C. Rodriguez-Galan
This study shows that systemic co-expression of IL-12 and IL-18 leads to IFN-γ-dependent microglia activation and recruitment of inflammatory monocytes into the brain, contributing to neuroinflammation.
bioRxiv · Jul 30, 2020Immunology