Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre ; LSL-KrasG12D/+) mice
M. T. Walcheck, M. Nukaya, E. A. Ranheim, K. A. Matkowskyj, S. M. Ronnekleiv-Kelly
This study shows that Pdx1 expression in hematopoietic cells of KC mice activates KrasG12D, leading to T-ALL and thymic tumors, with 20% of mice developing the disease by 9 months.
bioRxiv · May 17, 2022Cancer Biology