Author

K. A. Matkowskyj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. A. Pasch· 2 shared C. M. Sprackling· 2 shared D. A. Deming· 2 shared I. M. Ong· 2 shared M. C. Skala· 2 shared M. Nukaya· 2 shared M. T. Walcheck· 2 shared S. M. Ronnekleiv-Kelly· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

C. A. Pasch

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Author profile →

5 papers

Recent·Most cited

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

C. L. Green, M. E. Trautman, R. Babygirija, R. Jain, K. Chaiyakul, H. H. Pak, A. Bleicher, G. Novak, M. M. Sonsalla, C.-Y. Yeh, M. F. Calubag, T. T. Liu, V. Flores, S. Newman, W. A. Ricke, , D. Lamming

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

bioRxiv · Oct 6, 2022Physiology

Chronic Jetlag Accelerates Pancreatic Neoplasia in Conditional Kras-Mutant Mice

P. B. Schwartz, M. T. Walcheck, M. Nukaya, D. M. Pavelec, K. A. Matkowskyj, S. M. Ronnekleiv-Kelly

This study shows chronic jetlag accelerates pancreatic cancer in mice with Kras mutations by affecting fibroblasts rather than cancer cells directly.

bioRxiv · Jul 18, 2022Cancer Biology

Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre ; LSL-KrasG12D/+) mice

M. T. Walcheck, M. Nukaya, E. A. Ranheim, K. A. Matkowskyj, S. M. Ronnekleiv-Kelly

This study shows that Pdx1 expression in hematopoietic cells of KC mice activates KrasG12D, leading to T-ALL and thymic tumors, with 20% of mice developing the disease by 9 months.

bioRxiv · May 17, 2022Cancer Biology

Integrating Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity

J. D. Kratz, S. Rehman, K. A. Johnson, A. A. Gillette, A. Sunil, P. F. Favreau, C. A. Pasch, D. Miller, L. C. Zarling, A. H. Yeung, L. Clipson, S. J. Anderson, A. K. DeZeeuw, C. M. Sprackling, K. K. Lemmon, , D. A. Deming

The paper evaluates individual patient-derived cancer organoids using optical metabolic imaging to predict therapeutic response and identify subclonal populations and resistance mechanisms.

bioRxiv · Oct 15, 2021 · PreprintCancer Biology

Optical Metabolic Imaging of Heterogeneous Drug Response in Pancreatic Cancer Patient Organoids

J. T. Sharick, C. M. Walsh, C. M. Sprackling, C. A. Pasch, A. A. Parikh, K. A. Matkowskyj, D. A. Deming, M. C. Skala

This study uses optical metabolic imaging to predict pancreatic cancer patient treatment response by analyzing cellular heterogeneity in organoids.

bioRxiv · Feb 6, 2019Bioengineering