TGF-β-driven downregulation the expression of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts
O. Contreras, H. Soliman, M. Theret, F. M. V. Rossi, E. Brandan
The paper shows TGF-β reduces TCF7L2 expression in PDGFR+ fibroblasts via the ubiquitin-proteasome system and HDACs, impacting Wnt signaling in tissue repair.
bioRxiv · Jan 5, 2020 · PreprintCell Biology