Author

O. Contreras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

F. M. V. Rossi· 2 shared H. Soliman· 2 shared M. Theret· 2 shared A. Wu· 1 shared C. K. Chang· 1 shared E. Brandan· 1 shared F. f. Li· 1 shared L. Rempel· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

F. M. V. Rossi

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3 papers

Recent·Most cited

Single-Cell Transcriptome Dynamics of the Autotaxin-Lysophosphatidic Acid Axis During Muscle Regeneration Reveal Proliferative Effects in Mesenchymal Fibro-Adipogenic Progenitors

O. Contreras, R. P. Harvey

The paper analyzes single-cell RNA sequencing data to show the dynamic expression of the ENPP2-LPAR-PLPP axis in skeletal muscle regeneration, revealing its role in regulating FAP proliferation and differentiation.

bioRxiv · Jul 2, 2022Cell Biology

Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battle

M. Theret, M. Low, L. Rempel, F. f. Li, L. W. Tung, O. Contreras, C. K. Chang, A. Wu, H. Soliman, F. M. V. Rossi

The paper screens drugs to block fibrogenic differentiation in Duchenne Muscular Dystrophy mice, but finds no significant improvement in muscle histopathology despite in vitro hits.

bioRxiv · Jan 20, 2021 · PreprintCell Biology

TGF-β-driven downregulation the expression of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts

O. Contreras, H. Soliman, M. Theret, F. M. V. Rossi, E. Brandan

The paper shows TGF-β reduces TCF7L2 expression in PDGFR+ fibroblasts via the ubiquitin-proteasome system and HDACs, impacting Wnt signaling in tissue repair.

bioRxiv · Jan 5, 2020 · PreprintCell Biology