Author

E. C. Ledgerwood

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Dunstan-Harrison· 1 shared D. C. Singleton· 1 shared G. N. L. Jameson· 1 shared I. Kass· 1 shared K. O. McDonald· 1 shared M. A. Black· 1 shared M. B. Hampton· 1 shared M. F. Taylor· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

C. Dunstan-Harrison

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Author profile →

3 papers

Recent·Most cited

Megakaryocyte maturation involves activation of the adaptive unfolded protein response

M. Faiz, M. L. Kalev-Zylinska, C. Dunstan-Harrison, D. C. Singleton, M. P. Hay, E. C. Ledgerwood

This study shows that an adaptive unfolded protein response (UPR) is involved in human megakaryocyte differentiation without causing ER stress-induced apoptosis.

bioRxiv · Jul 26, 2023Cell Biology

Insights into H2O2-induced signaling in Jurkat cells from analysis of gene expression

M. F. Taylor, M. A. Black, M. B. Hampton, E. C. Ledgerwood

The paper investigates the transcriptomic response of Jurkat cells to H2O2, identifying extensive gene expression changes and associated pathways.

bioRxiv · Oct 20, 2022Cell Biology

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity

M. Fellner, R. Parakra, K. O. McDonald, I. Kass, G. N. L. Jameson, S. M. Wilbanks, E. C. Ledgerwood

The paper investigates how pathogenic cytochrome c variants alter structure and dynamics, linking these changes to increased apoptotic activity and peroxidase function.

bioRxiv · Jun 14, 2020Biochemistry