The cIAP ubiquitin ligases sustain type 3 γδ T and innate lymphoid cells during aging to allow normal cutaneous and mucosal responses
J. Rizk, U. M. Morbe, R. Agerholm, I. Ulmert, E. C. Tardos, D. Kadekar, M. V. Baglioni, M. T. Vinals, V. Bekiaris
This study shows that cIAP1/2 ubiquitin ligases are essential in early life for maintaining IL-17-producing γδT17 and ILC3 cells, which are critical for immune responses during aging.
bioRxiv · May 14, 2020Immunology