Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor
L. M. Godsel, Q. R. Roth-Carter, J. L. Koetsier, L. C. Tsoi, J. A. Broussard, G. N. Fitz, S. M. Lloyd, J. Kweon, A. L. Huffine, H. E. Burks, M. Hegazy, S. Amagai, P. W. Harms, J. L. Johnson, G. Urciuoli, , K. J. Green
This study investigates the systemic inflammatory response in Dsg1-deficient mice and humans, revealing a psoriatic-like IL-17-skewed inflammation due to genetic Dsg1 loss.
bioRxiv · Dec 1, 2020 · PreprintImmunology