The Frizzled-ligand Norrin acts as a tumour suppressor linking oncogenic RAS signalling to p53
G. Sulli, E. D'Elia, M. C. Moroni
The paper identifies Norrin as a tumour suppressor that links RAS signalling to p53, showing its role in suppressing transformation and its downregulation in several cancers.
bioRxiv · Jun 11, 2019 · PreprintCancer Biology