Bidirectional transfer of Engrailed homeoprotein across the plasma membrane requires PIP2
I. Amblard, E. Dupont, i. Alves, J. Miralves, I. Queguiner, A. JOLIOT
The paper demonstrates that PIP2 and cholesterol are essential for Engrailed2 homeoprotein translocation across the plasma membrane, with both secretion and internalization regulated by PIP2 levels.
bioRxiv · Jan 21, 2020Cell Biology