Ligand-induced shifts in conformational ensembles that predict transcriptional activation
S. H. Khan, S. M. Braet, S. J. Koehler, E. Elacqua, G. S. Anand, C. D. Okafor
The paper uses molecular dynamics simulations and experimental validation to show that conformational ensembles of nuclear receptors predict ligand-induced transcriptional responses.
bioRxiv · May 29, 2022 · PreprintBiochemistry