G. S. Anand

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics

The paper tracks changes in SARS-CoV-2 spike protein dynamics across variants using hydrogen/deuterium exchange mass spectrometry, revealing progressive stabilization of the trimer stalk and enhanced NTD dynamics in Omicron BA.1.

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

This paper identifies a pH-dependent charge cluster in flaviviral envelope proteins that influences domain dissociation and fusion through molecular dynamics simulations.

Ligand-induced shifts in conformational ensembles that predict transcriptional activation

The paper uses molecular dynamics simulations and experimental validation to show that conformational ensembles of nuclear receptors predict ligand-induced transcriptional responses.

GM1a functions as a coreceptor/ attachment factor for Dengue virus during infection in mammalian systems

This study identifies GM1a as a coreceptor/attachment factor for Dengue virus during infection in mammalian systems, showing it enhances infectivity and speeds virus movement.

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

This study shows SARS-CoV-2 spike protein binds LPS, which may enhance immune activation via TLR4, with conserved binding sites across variants.

The novel conserved NAD+ binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

The paper investigates how ACE2 binding to SARS-CoV-2 Spike protein allosterically affects proteolysis at distal cleavage sites and highlights potential therapeutic targets.

Infectivity of dengue virus serotypes 1 and 2 is correlated to E protein intrinsic dynamics but not to envelope conformations

This study investigates the relationship between dengue virus serotypes 1 and 2 infectivity and the dynamics of their envelope proteins, finding that intrinsic dynamics, not envelope conformations, correlate with infectivity.