Pharmacology & ToxicologybioRxiv
Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supra-Lethal Dose of Soman in Cynomolgus Monkeys Post-treated with Conventional Antidotes
M. Lane, D. Carter, J. D. Pescrille…·E. X. Albuquerque
This study shows oral galantamine pretreatment reduces acute toxicity of a high dose of soman in monkeys treated with standard antidotes, improving survival and reducing neuronal damage.
DOI 10.1124/jpet.120.265843