Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in absence of growth
E. G. Rens, M. T. Zeegers, I. Rabbers, A. Szabo, R. M. H. Merks
The paper proposes a mechanism for epithelial branching morphogenesis without proliferation or mesenchymal interaction, showing autocrine TGFβ1 inhibits protrusions and drives branching through curvature-dependent inhibition.
bioRxiv · May 15, 2020Biophysics