A. Szabo

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

A matter of salt: global assessment of the effect of salt ionic composition as a driver of aquatic bacterial diversity

This study assesses how ionic composition affects microbial diversity in inland saline aquatic habitats, finding it explains more variability than salinity or geographic location.

Patient-derived functional immuno-oncology platform identifies responders to ATR inhibitor and immunotherapy combinations in ovarian cancer

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

This study shows that CB2R on microglia drives neuroinflammation in GVHD by promoting T cell activation and neuronal death, and that targeting CB2R reduces inflammation without worsening systemic GVHD.

Single-cell spatial atlas of tertiary lymphoid structures in ovarian cancer

This study creates a single-cell spatial atlas of tertiary lymphoid structures (TLSs) in ovarian cancer, revealing distinct TME composition, gene expression profiles, and cell-cell interactions associated with TLSs.

High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue

This study develops a base-editing strategy to correct the ABCA4 mutation in mice, non-human primates, and human retinal tissue, achieving high editing rates in vivo.

Contrasting Response of Microeukaryotic and Bacterial Communities to the Interplay of Seasonality and Stochastic Events in Shallow Soda Lakes

The paper examines how seasonal changes and stochastic events affect microeukaryotic and bacterial communities in shallow soda lakes, finding that stochastic events cause more pronounced deviations in microeukaryotes than bacteria.

A TYPE 2 INNATE LYMPHOID CELL-INTERLEUKIN 9 CIRCUIT INDUCES PANETH CELL METAPLASIA AND SMALL INTESTINAL REMODELING

This study identifies an ILC2/IL-9 immune circuit triggered by extra-intestinal disease that induces Paneth cell metaplasia and small intestinal remodeling in a murine model of CML.

Zymosan-induced leukocyte and cytokine changes in pigs: a new model for streamlined drug testing against severe COVID-19

This paper develops a pig model of zymosan-induced immune and hemodynamic changes that mimic late-stage COVID-19 symptoms, enabling drug testing for cytokine storm.

Microbial stowaways - waterbirds as dispersal vectors of aquatic pro- and microeukaryotic communities

This study shows waterbirds transport aquatic microbial communities via droppings, with greylag geese dispersing 28% of prokaryotes and 19% of microeukaryotes.

Grazing pressure-induced shift in planktonic bacterial communities with the dominance of acIII-A1 actinobacterial lineage in soda pans

The paper investigates seasonal changes in soda pan bacterial communities, finding that grazing pressure by microcrustaceans drives a shift toward actinobacterial dominance.

Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in absence of growth

The paper proposes a mechanism for epithelial branching morphogenesis without proliferation or mesenchymal interaction, showing autocrine TGFβ1 inhibits protrusions and drives branching through curvature-dependent inhibition.

Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder

This study finds that cannabis use is linked to higher soluble gp130 levels in schizophrenia patients but not in bipolar disorder patients, independent of immune cell modulation.

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.