ApoE isoforms establish distinct antioxidant trajectories across the aging brain
S. J. Shemtov, M. Cacciottolo, A. Christensen, B. Li, A. Haghani, M. C. Rice, H. Anson, C. S. Chung, W. Cohn, H. Zhang, W. J. Mack, A. Hiniker, C. Lee, T. E. Morgan, E. Head, , Max A. Thorwald
This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.
bioRxiv · Nov 9, 2026 · PreprintEvolutionary Biology