Base pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar Ribonucleoproteins
E. K. Kelly, D. P. Czekay, U. Kothe
This study shows that base pairing between H/ACA guide RNA and substrate RNA affects pseudouridylation kinetics but not binding affinity, providing insights into RNA recognition mechanisms.
bioRxiv · Jul 11, 2019Biochemistry