14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
T. Karlberg, P. Hornyak, A. F. Pinto, S. Milanova, M. Ebrahimi, M. Lindberg, N. Pullen, A. Nordstrom, E. Loverli, R. Caraballo, E. V. Wong, K. Nareoja, A.-G. Thorsell, M. Elofsson, E. M. De La Cruz, , H. Schuler
This study identifies a novel hydrophobic interface between 14-3-3 proteins and Pseudomonas exotoxins-S and -T, showing 14-3-3 activates these toxins by preventing aggregation, independent of their C-terminal phosphopeptide binding motifs.
bioRxiv · Jun 8, 2018Biochemistry