BACE1, but not BACE2, function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice
T. W. Rosahl, L. A. Hyde, P. T. Reilly, M.-F. Champy, K. J. Belongie, B. Petit-Demouliere, T. Sorg, H. Jacobs, R. Terry, J. T. Scott, J. N. Cuming, E. M. Parker, M. E. Kennedy
This study shows that BACE1, but not BACE2, knockout improves metabolic outcomes in mice on a high-fat diet, suggesting BACE1 inhibition may enhance metabolic homeostasis.
bioRxiv · Dec 20, 2021 · PreprintPhysiology