Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1
I. M. S. de Vera, P. Munoz-Tello, V. Dharmarajan, D. P. Marciano, E. Matta-Camacho, P. K. Giri, J. Shang, T. S. Hughes, M. Rance, P. R. Griffin, D. J. Kojetin
This study shows the Nurr1 ligand-binding domain has a dynamic, solvent-accessible pocket that can bind unsaturated fatty acids, challenging the notion that it lacks a canonical ligand-binding pocket.
bioRxiv · Apr 17, 2018Biophysics