Author

T. S. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

D. J. Kojetin· 2 shared J. Shang· 2 shared P. Munoz-Tello· 2 shared D. P. Marciano· 1 shared E. Matta-Camacho· 1 shared H. Lin· 1 shared I. M. S. de Vera· 1 shared J. Bass· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

D. J. Kojetin

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2 papers

Recent·Most cited

Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ

J. Shang, R. Brust, S. A. Mosure, J. Bass, P. Munoz-Tello, H. Lin, T. S. Hughes, M. Tang, Q. Ge, T. M. Kamekencka, D. J. Kojetin

The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.

bioRxiv · Nov 1, 2018Biochemistry

Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1

I. M. S. de Vera, P. Munoz-Tello, V. Dharmarajan, D. P. Marciano, E. Matta-Camacho, P. K. Giri, J. Shang, T. S. Hughes, M. Rance, P. R. Griffin, D. J. Kojetin

This study shows the Nurr1 ligand-binding domain has a dynamic, solvent-accessible pocket that can bind unsaturated fatty acids, challenging the notion that it lacks a canonical ligand-binding pocket.

bioRxiv · Apr 17, 2018Biophysics