Author

P. R. Griffin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:protein folding & dynamics· 6 Organism:human· 4 Assay:structural biology· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. R. Chang· 3 shared T. S. Strutzenberg· 3 shared V. Dharmarajan· 3 shared E. Arnold· 2 shared F. X. Ruiz· 2 shared J. Timm· 2 shared P. Munoz-Tello· 2 shared R. Yadav· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiophysics

M. R. Chang

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Author profile →

11 papers

Recent·Most cited

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

S. Baroi, P. J. Czernik, M. Khan, J. Letson, E. Crowe, A. Chougule, P. R. Griffin, C. J. Rosen, B. Lecka-Czernik

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

bioRxiv · Apr 4, 2024Physiology

Structural basis of interdomain communication in PPARγ

S. A. Mosure, P. Munoz-Tello, K.-T. Kuo, B. MacTavish, X. Yu, D. Scholl, C. C. Williams, T. S. Strutzenberg, J. Li, J. Bass, R. Brust, E. Kalkhoven, A. A. Deniz, P. R. Griffin, D. Kojetin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

bioRxiv · Jul 13, 2022 · PreprintBiophysics

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

R. Yadav, V. V. Courouble, S. K. Dey, J. J. E. K. Harrison, J. Timm, J. B. Hopkins, R. L. Slack, S. G. Sarafianos, F. X. Ruiz, P. R. Griffin, E. Arnold

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

bioRxiv · May 27, 2022Biochemistry

RORβ modulates a gene program that is protective against articular cartilage damage

P. R. Griffin, M. R. Chang

This study shows that RORβ modulates a gene program that supports chondrogenesis and protects against OA by regulating FGFR signaling pathways.

bioRxiv · May 5, 2022Cell Biology

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

T. S. Strutzenberg, S. J. Novick, R. D. Garcia-Ordonez, C. Doebelin, Y. He, M. R. Chang, T. M. Kamenecka, P. R. Griffin

This study investigates conformational changes in RORγ during DNA recognition and coregulator engagement using structural proteomics and small angle X-ray scattering.

bioRxiv · May 25, 2021Biophysics

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

V. Courouble, S. Dey, R. Yadav, J. Timm, J. Harrison, F. X. Ruiz, E. Arnold, P. R. Griffin

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

bioRxiv · Mar 6, 2021 · PreprintBiophysics

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

T. S. Strutzenberg, R. Garcia-Ordonez, S. Novick, H. Park, M. R. Chang, C. Doebellin, Y. He, R. Patouret, T. Kamenecka, P. R. Griffin

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

bioRxiv · Mar 26, 2019Biophysics

Disorganization of the histone core promotes organization of heterochromatin into phase-separated droplets

S. Sanulli, M. J. Trnka, V. Dharmarajan, R. W. Tibble, B. D. Pascal, A. L. Burlingame, P. R. Griffin, J. D. Gross, G. J. Narlikar

This study shows that the S. pombe HP1 protein Swi6 promotes chromatin compaction through phase-separated droplets by disorganizing the histone core and increasing histone residue accessibility.

bioRxiv · Nov 18, 2018 · PreprintBiophysics

Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d

C. Zhang, S. Konermann, N. J. Brideau, P. Lotfy, S. J. Novick, T. Strutzenberg, P. R. Griffin, P. D. Hsu, D. Lyumkis

The paper determines the structural basis of CRISPR-Cas13d's RNA-guided ribonuclease activity through cryo-EM and biochemical analysis, revealing its molecular architecture and activation mechanisms.

bioRxiv · May 4, 2018Biochemistry

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

S. W. Fanning, R. Jeselsohn, V. Dharmarajan, C. G. Mayne, M. Karimi, G. Buchwalter, R. Houtman, W. Toy, C. E. Fowler, M. Laine, K. E. Carlson, T. A. Martin, J. Nowak, J. C. Nwachukwu, D. J. Hosfield, , G. L. Greene

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

bioRxiv · Apr 23, 2018Cancer Biology

Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1

I. M. S. de Vera, P. Munoz-Tello, V. Dharmarajan, D. P. Marciano, E. Matta-Camacho, P. K. Giri, J. Shang, T. S. Hughes, M. Rance, P. R. Griffin, D. J. Kojetin

This study shows the Nurr1 ligand-binding domain has a dynamic, solvent-accessible pocket that can bind unsaturated fatty acids, challenging the notion that it lacks a canonical ligand-binding pocket.

bioRxiv · Apr 17, 2018Biophysics