Author

E. N. Weinstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. G. Green· 1 shared A. N. Amin· 1 shared B. Wang· 1 shared D. Ding· 1 shared D. Marks· 1 shared D. S. Marks· 1 shared J. Frazer· 1 shared M. T. Laub· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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1 shared paperEvolutionary Biology

A. G. Green

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2 papers

Recent·Most cited

Non-identifiability and the Blessings of Misspecification in Models of Molecular Fitness

E. N. Weinstein, A. N. Amin, J. Frazer, D. Marks

This paper shows that fitness cannot be reliably estimated from sequence data alone and that current models work well due to misspecification, not accuracy.

bioRxiv · Jan 29, 2022 · PreprintEvolutionary Biology

Coevolution of interacting proteins through non-contacting and non-specific mutations

D. Ding, A. G. Green, B. Wang, T.-L. V. Lite, E. N. Weinstein, D. S. Marks, M. T. Laub

The paper identifies enabling mutations in a bacterial toxin that tolerate antitoxin mutations, showing non-specific tolerance despite covariation primarily between contacting residues.

bioRxiv · Oct 7, 2021 · PreprintEvolutionary Biology