B. Wang

REAL-TIME VISUALIZATION OF SPLICEOSOME ASSEMBLY REVEALS BASIC PRINCIPLES OF SPLICE SITE SELECTION

The paper applies a kinetic proofreading model to elucidate how transient U2AF binding leads to high fidelity splice site selection.

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

Notch Signaling in regulating Bone-derived Nanoparticles (BNPs) enhanced Osteogenic Differentiation

This study investigates how bone-derived nanoparticles (BNPs) enhance osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling, specifically by increasing Dll4 expression.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

Regeneration in the absence of canonical neoblasts in an early branching flatworm

This study shows that whole-body regeneration in a flatworm occurs without conventional neoblasts, challenging the idea that neoblasts are essential for regeneration.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Post-translational Modification of α-Synuclein Modifies Monomer Dynamics and Aggregation Kinetics

This study examines how O-GlcNAcylation at T72 and S87 of α-synuclein affects its monomer dynamics and aggregation kinetics, revealing differential impacts on protein behavior.

CASTpFold: Computed Atlas of Surface Topography of the universe of protein Folds

CASTpFold extends the CASTp tool to provide accurate and comprehensive protein surface topography analysis using AlphaFold2 structures and functional annotations.

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

A genetic and microscopy toolkit for live imaging of whole-body regeneration in Macrostomum lignano

This paper develops a toolkit for live imaging of whole-body regeneration in flatworms, revealing neuron regenerative limitations and independent nerve cord reconnection.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy

This study uses third-harmonic generation microscopy to image plant roots and microbes in their natural environment without labels.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Exploring Behavioral and Neural Dynamics of Social Interactions during the Juvenile Stage in a Mouse Model of Fragile X Syndrome

This study examines social behavior and cortical activity in juvenile Fmr1 knockout and heterozygous mice, revealing sex- and genotype-dependent differences in social interactions and oscillatory brain activity.

Phylogenomics resolves a 100-year-old debate regarding the evolutionary history of caddisflies (Insecta: Trichoptera)

This study resolves a century-old debate on caddisfly phylogeny by analyzing genome data from 111 species, clarifying the evolutionary relationships of 'cocoon-makers' and estimating divergence times.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

Asymmetric Fin Shape changes Swimming Dynamics of Ancient Marine Reptiles' Soft Robophysical Models

This paper uses soft robotic models to study how asymmetrical fin shapes affected swimming dynamics in ancient marine reptiles, finding that certain fin shapes helped compensate for buoyancy.

Prognostic Significance of preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP in Patients with Endometrial cancer

The paper develops a risk score using preoperative serum biomarkers CA125, CEA, and AFP to predict progression-free and overall survival in endometrial cancer patients, validated with nomograms.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

The triose phosphate/phosphate translocator exports photosynthetic glyceraldehyde 3-phosphate from chloroplasts to trigger antimicrobial immunity in plants.

This study identifies AtTPT as a chloroplast transporter that exports glyceraldehyde 3-phosphate to trigger antimicrobial immunity in plants.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

Synthetase and Hydrolase Specificity Collectively Excludes Deoxyguanosine from Bacterial Alarmone

The paper shows that bacterial alarmone synthetases and hydrolases exclude 2-deoxyguanosine due to its inability to be degraded, preventing deleterious 2dG alarmone production.

Microbiome-induced Increases and Decreases in Bone Tissue Strength can be Initiated After Skeletal Maturity

This study shows that altering the gut microbiome in adult mice can reduce or restore bone matrix strength, with sex-specific effects.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

Acetylation of WCC is dispensable for the core circadianclock but differentially regulates acute light responses in Neurospora

This study shows acetylation and mono-methylation of WCC in Neurospora are not essential for circadian rhythm timing but influence light responses.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.