Coevolution of interacting proteins through non-contacting and non-specific mutations
D. Ding, A. G. Green, B. Wang, T.-L. V. Lite, E. N. Weinstein, D. S. Marks, M. T. Laub
The paper identifies enabling mutations in a bacterial toxin that tolerate antitoxin mutations, showing non-specific tolerance despite covariation primarily between contacting residues.
bioRxiv · Oct 7, 2021 · PreprintEvolutionary Biology