Inactivation of the Niemann Pick C1 cholesterol transporter 1 (NPC1) restricts SARS-CoV-2 infection
P. La Rosa, J. Tiberi, E. Palermo, S. Tiano, M. Cortese, J. Hiscott, M. T. Fiorenza
This study shows that inactivating NPC1 reduces SARS-CoV-2 infection by trapping ACE2 in lysosomes and disrupting viral entry.
bioRxiv · Dec 13, 2023 · PreprintCell Biology