Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15
J. Yu, T. Guo, A. Gupta, E. M. Llano, N. Wajahat, S. Slater, Q. Deng, E. Akbay, J. Shelton, B. M. Evers, Z. Wu, I. Tzameli, E. Pashos, J. Minna, P. Iyengar, R. E. Infante
This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.
bioRxiv · Jun 14, 2024 · PreprintCancer Biology