Lipid-derived electrophiles induce covalent modification and aggregation of Cu,Zn-superoxide dismutase in a hydrophobicity-dependent manner
L. S. Dantas, L. G. Viviani, A. Inague, E. Piccirillo, L. R. Rezende, G. E. Ronsein, O. Augusto, M. H. Medeiros, A. T. Amaral, S. Miyamoto
This study shows that hydrophobic lipid-derived electrophiles induce covalent modification and aggregation of SOD1, with aggregation levels positively correlated to aldehyde hydrophobicity.
bioRxiv · Aug 29, 2019Biochemistry