S. Miyamoto

Plasmalogen oxidation induces the generation of excited molecules and electrophilic lipid species

This study shows that oxidized plasmalogens generate excited triplet carbonyls and electrophilic lipid species, revealing their prooxidant properties.

Plasma Oxylipin Profiling by High Resolution Mass Spectrometry Reveal Signatures of Inflammation and Hypermetabolism in Amyotrophic Lateral Sclerosis

This paper develops a high-throughput LC-HRMS method to analyze oxylipins in ALS rat models and identifies altered oxylipin profiles associated with inflammation and hypermetabolism.

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

vRNA-vRNA interactions in influenza A virus HA vRNA packaging

The paper identifies direct RNA-RNA interactions between HA and PB2 vRNAs in influenza A virus that are critical for selective genome packaging and viral replication.

Timelapse viability assay to detect division and death of primary multiple myeloma cells in response to drug treatments with single cell resolution

The paper develops tools to assess drug response in primary multiple myeloma cells with single-cell resolution, enabling functional analysis of therapy response in patient-derived samples.

Calorie Restriction Maintains Mitochondrial Function and Redox Balance Avoiding Lipidomic Reprogramming during Isoproterenol-Induced Cardiac Hypertrophy

This study shows calorie restriction prevents cardiac hypertrophy-induced lipidomic changes, mitochondrial dysfunction, and oxidative stress in vivo.

Resource sharing by outer membrane vesicles from a citrus pathogen

This study identifies outer membrane vesicles from Xanthomonas citri as resource-sharing structures containing nutrients and enzymes that support bacterial growth and virulence.

Influenza virus ribonucleoprotein complex formation occurs in the nucleolus

This study identifies the nucleolus as the site of vRNP formation and vRNA replication in influenza virus-infected cells.

A Novel DNA Chromatography Method to Distinguish M. abscessus Subspecies and Macrolide Susceptibility

This paper develops a DNA chromatography method to rapidly distinguish M. abscessus subspecies and determine macrolide susceptibility with high accuracy.

Distinct photooxidation-induced cell death pathways lead to selective killing of human breast cancer cells

This study identifies distinct photooxidation-induced cell death pathways in human breast cancer cells, showing MB-PDT selectively kills tumorigenic cells through ferroptosis and necroptosis.

Lipid-derived electrophiles induce covalent modification and aggregation of Cu,Zn-superoxide dismutase in a hydrophobicity-dependent manner

This study shows that hydrophobic lipid-derived electrophiles induce covalent modification and aggregation of SOD1, with aggregation levels positively correlated to aldehyde hydrophobicity.