Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification
E. D. Pratt, R. W. Cowan, S. L. Manning, E. Qiao, H. Cameron, K. Schradle, D. M. Simeone, D. B. Zhen
The paper introduces MED-Amp, a method for highly sensitive detection of rare KRAS mutations in liquid biopsy samples, achieving 86% detection in metastatic pancreatic cancer plasma.
bioRxiv · Apr 24, 2019Bioengineering