Author

D. M. Simeone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. A. Alaniz· 1 shared A. Heguy· 1 shared A. Tsirigos· 1 shared A. W. Lund· 1 shared B. Magnuson· 1 shared C. A. Loomis· 1 shared C. Hajdu· 1 shared C. Kumar-Sinha· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. A. Alaniz

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Author profile →

3 papers

Recent·Most cited

Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

G. Werba, D. Weissinger, E. A. Kawaler, E. Zhao, D. Kalfakakou, S. Dhara, G. Oh, X. Jing, N. Beri, L. Khanna, T. Gonda, P. Oberstein, C. Hajdu, C. A. Loomis, A. Heguy, , D. M. Simeone

This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.

bioRxiv · May 24, 2022Cancer Biology

Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification

E. D. Pratt, R. W. Cowan, S. L. Manning, E. Qiao, H. Cameron, K. Schradle, D. M. Simeone, D. B. Zhen

The paper introduces MED-Amp, a method for highly sensitive detection of rare KRAS mutations in liquid biopsy samples, achieving 86% detection in metastatic pancreatic cancer plasma.

bioRxiv · Apr 24, 2019Bioengineering

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells

E. Abel, M. Goto, B. Magnuson, S. Abraham, N. Ramanathan, E. Hotaling, A. A. Alaniz, C. Kumar-Sinha, M. L. Dziubinski, S. Urs, L. Wang, J. Shi, M. Waghray, M. Ljungman, H. C. Crawford, D. M. Simeone

This study identifies HNF1A as a central regulator of pancreatic cancer stem cells and a novel oncogene in pancreatic ductal adenocarcinoma.

bioRxiv · Dec 22, 2017Cancer Biology