Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1
S. Kar, S. Sen, S. Maji, Ruturaj, R. Paul, S. Dutt, B. Mondal, R. Schreiner, E. R. Boulan, D. Sengupta, A. Gupta
The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).
bioRxiv · Aug 3, 2021 · PreprintCell Biology