Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease
B. Qin, G. B. Craven, P. Hou, X. Lu, E. S. Child, R. M. L. Morgan, A. Armstrong, D. J. Mann, S. Cui
The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.
bioRxiv · Nov 6, 2020Biochemistry