Time machine: Can a dye from 1928 be re-purposed for modern, fluorescence-based detection of amyloid-like fibrils?
O. I. Antimonova, N. A. Grudinina, V. V. Egorov, V. V. Ilyin, Y. A. Zabrodskaya, E. S. Ramsay, V. A. Polukeev, M. M. Shavlovsky
The paper synthesizes a dye similar to fluorene and Congo red, showing it changes fluorescent spectrum when interacting with amyloid-like fibrils of proteins like lysozyme and insulin.
bioRxiv · Jun 10, 2019Biochemistry