Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function
K. M. Hudock, M. S. Collins, M. A. Imbrogno, J. J. Brewington, A. Ziady, N. Zhang, J. M. Snowball, Y. Xu, B. Carey, Y. Horio, S. O'Grady, E. Kopras, J. Meeker, H. Morgan, A. Ostmann, , J. P. Clancy
This study shows that neutrophil extracellular traps (NETs) disrupt airway epithelial barrier function by causing cell death and E-cadherin degradation, which can be mitigated by alpha-1 antitrypsin.
bioRxiv · Mar 18, 2022 · PreprintImmunology