N. Zhang

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Related PP2C phosphatases Pic3 and Pic12 negatively regulate immunity in tomato to Pseudomonas syringae

This study identifies Pic3 and Pic12 as PP2C phosphatases that negatively regulate tomato immunity against Pseudomonas syringae through flagellin-independent pathways.

Interspecies interaction reshapes the fitness landscape of evolved genotypes

This study investigates how interspecies interactions shape genetic and phenotypic diversity in a two-species microbial consortium over evolutionary time.

Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

Bridging the Gap: biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

This study investigates bacterial-fungal interactions between Bacillus velezensis and Trichoderma guizhouense, showing biofilm-mediated colonization and gene expression changes that reveal complex dynamics in soil microbiota.

PP2C phosphatase Pic14 negatively regulates tomato Pto/Prf-triggered immunity by inhibiting MAPK activation

This paper identifies Pic14 as a negative regulator of Pto/Prf-triggered immunity in tomato by inhibiting MAPK activation through dephosphorylation of Mkk2.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

SlSAURs, targeted by SlSTOP1, inhibit SlPP2C.Ds to modulate H+-ATPase and tomato root elongation under aluminum stress

This study identifies SlSAURs as regulators of root elongation under aluminum stress by interacting with SlPP2C.Ds to modulate H+-ATPase activity.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation

This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

Role of Staphylococcus aureus Buoyant Density in the Development of Biofilm Associated Antibiotic Resistance

This study shows that Staphylococcus aureus cells with lower buoyant density resist antibiotics more and form biofilms at air-liquid interfaces, while higher buoyant density cells are more antibiotic-sensitive and form biofilms on liquid-solid interfaces.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

Epithelial organoid supports resident memory CD8 T cell differentiation

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging

The paper introduces a multimodal imaging platform to measure multiple cerebral hemodynamic parameters with high spatiotemporal resolution and applies it to study brain responses to hypercapnia.

Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

This study examines NET composition variability across healthy individuals and finds DNA content correlates with NET components and epithelial barrier disruption.

Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

This study identifies a third interaction between Myo5a and Mlph, involving the exon-G region of Myo5a and Mlph-ABD, which is required for melanosome association.

Beta-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.

Cardiac disease diagnosis based on GAN in case of missing data

This paper proposes AGAN, a GAN-based method for filling missing data in cardiac disease datasets, improving data quality and downstream classification accuracy.

Natural variation of immune epitopes reveals intrabacterial antagonism

The paper analyzes natural variation in immune epitopes across bacterial genomes to reveal a mechanism of intrabacterial immune evasion.