The dynamics of hinge flexibility in receptor bound immunoglobulin E revealed by electron microscopy
R. K. Jensen, M. Miehe, R. Gandini, M. H. Joergensen, E. Spillner, G. R. Andersen
This paper uses cryo-EM and ns-EM to reveal distinct conformations of IgE bound to its receptor, showing that one Fab arm is fixed while the other is flexible, and that this flexibility affects IgE function.
bioRxiv · Feb 17, 2023 · PreprintImmunology