Author

M. H. Joergensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

R. K. Jensen· 2 shared A. V. Almeida· 1 shared E. Spillner· 1 shared E. Tranchant· 1 shared G. R. Andersen· 1 shared G. R. R. Andersen· 1 shared H. G. Olesen· 1 shared H. Pedersen· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

R. K. Jensen

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2 papers

Recent·Most cited

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

T. A. Gadeberg, M. H. Joergensen, H. G. Olesen, J. Lorentzen, S. L. Harwood, A. V. Almeida, M. U. Fruergaard, R. K. Jensen, P. Kanis, H. Pedersen, E. Tranchant, S. V. Petersen, I. B. Thoegersen, J. A. Lyons, J. J. Enghild, G. R. R. Andersen

This study uses cryo-EM to analyze the structural changes in C3 during hydrolysis, revealing a dynamic opening in the macroglobulin ring that allows domain translocation.

bioRxiv · Apr 15, 2024Biochemistry

The dynamics of hinge flexibility in receptor bound immunoglobulin E revealed by electron microscopy

R. K. Jensen, M. Miehe, R. Gandini, M. H. Joergensen, E. Spillner, G. R. Andersen

This paper uses cryo-EM and ns-EM to reveal distinct conformations of IgE bound to its receptor, showing that one Fab arm is fixed while the other is flexible, and that this flexibility affects IgE function.

bioRxiv · Feb 17, 2023 · PreprintImmunology