Cell BiologybioRxiv
The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
E. T. Parkin, J. E. Hammond, M. D. Hodges
This study shows dichloroacetate inhibits amyloidogenic and promotes non-amyloidogenic processing of amyloid precursor protein in cells.
DOI 10.1371/journal.pone.0255715