Impaired HSF1 transactivation drives proteostasis collapse and senescent phenotype of IPF lung fibroblast.
K. Cuevas-Mora, W. Roque, D. Sales, J. D. Ritzenthaler, E. Torres-Gonzales, A. J. Halayko, I. O. Rosas, J. Roman, F. Romero
This study shows that impaired HSF1 transactivation leads to proteostasis collapse and senescent phenotype in IPF lung fibroblasts, suggesting HSF1 activation could treat lung fibrosis.
bioRxiv · Apr 10, 2020 · PreprintCell Biology