Microtubule Binding Kinetics of Membrane-bound Kinesin Predicts High Motor Copy Numbers on Intracellular Cargo
R. Jiang, S. R. Vandal, S. Park, S. Majd, E. Tüzel, W. O. Hancock
The paper measures the microtubule binding kinetics of membrane-bound kinesin-1 motors and finds that motor reattachment is not limited by diffusion but by intrinsic binding rates, predicting high motor copy numbers for long-range vesicle transport.
Proceedings of the National Academy of Sciences · Dec 10, 2019Peer-reviewedBiophysics