Atropselective Oxidation of 2,2’,3,3’,4,6’-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity
E. Uwimana, X. Li, C. Yeung, E. V. Patterson, H.-J. Lehmler
This study investigates the atropselective oxidation of PCB 132 by human liver microsomes, revealing inter-individual variability in metabolite formation and enantiomeric fractions.
bioRxiv · Apr 4, 2019Pharmacology & Toxicology