Author

H.-J. Lehmler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Pharmacology & Toxicology· 5

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

X. Li· 4 shared A. J. Klingelhutz· 2 shared A. Bullert· 1 shared A. Dailey· 1 shared A. Lopez-Juarez· 1 shared B. S. Cagle· 1 shared B. T. Colter· 1 shared B. Vats· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersPharmacology & Toxicology

X. Li

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5 papers

Recent·Most cited

Predicted Versus Observed Activity of PCB Mixtures Toward the Ryanodine Receptor

J. A. Griffin, X. Li, H.-J. Lehmler, E. B. Holland

The paper compares predicted and observed activity of PCB mixtures on the RyR1 receptor, finding that neither model perfectly predicts complex mixtures but predictions are within one magnitude of observed responses.

bioRxiv · Aug 22, 2023Pharmacology & Toxicology

Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure

A. Bullert, X. Li, C. Zhang, K. Lee, C. F. Pulliam, B. S. Cagle, J. A. Doorn, A. J. Klingelhutz, L. W. Robertson, H.-J. Lehmler

This study examines the distribution and metabolomic effects of PCB 52 in female rats after intraperitoneal exposure, finding metabolites in serum and liver with minor changes in serum metabolites.

bioRxiv · Jun 19, 2023Pharmacology & Toxicology

Toxicity impacts on human adipose MSCs acutely exposed to Aroclor and non-Aroclor mixtures of PCBs.

R. M. Behan-Bush, J. N. Liszewski, M. V. Schrodt, B. Vats, X. Li, H.-J. Lehmler, A. J. Klingelhutz, J. A. Ankrum

This study examines the toxicity of PCB mixtures on human adipose MSCs, finding two types of toxicity that impair growth and function.

bioRxiv · Nov 17, 2022Pharmacology & Toxicology

Atropselective Oxidation of 2,2’,3,3’,4,6’-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity

E. Uwimana, X. Li, C. Yeung, E. V. Patterson, H.-J. Lehmler

This study investigates the atropselective oxidation of PCB 132 by human liver microsomes, revealing inter-individual variability in metabolite formation and enantiomeric fractions.

bioRxiv · Apr 4, 2019Pharmacology & Toxicology

Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect susceptibility to developmental polychlorinated biphenyl exposure in mice: Relevance to studies of human neurological disorders

K. Klinefelter, M. K. Hooven, C. Bates, B. T. Colter, A. Dailey, S. K. Infante, I. Kania-Korwel, H.-J. Lehmler, A. Lopez-Juarez, C. P. Ludwig, C. P. Curran

This study shows genetic differences in Ahr and Cyp1a2 genes affect susceptibility to developmental PCB exposure in mice, with no strong link to Parkinson's disease risk.

bioRxiv · Sep 27, 2017Pharmacology & Toxicology