GPCR binding and JNK3 activation by arrestin-3 have different structural requirements
C. Zheng, L. D. Weinstein, K. K. Nguyen, A. Grewal, E. V. Gurevich, V. V. Gurevich
This study shows that GPCR binding and JNK3 activation by arrestin-3 require distinct structural features, with Lys-295 playing a key role in GPCR binding but not in JNK3 activation.
bioRxiv · May 1, 2023 · PreprintCell Biology