Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics
Y. Gao, E. B. Kabotyanski, E. Villegas, J. H. Shepherd, D. Acosta, C. Hamor, T. Sun, C. Montemayor-Garcia, X. He, L. E. Dobrolecki, T. F. Westbrook, M. T. Lewis, S. G. Hilsenbeck, X. H.- F. Zhang, C. M. Perou, J. M. Rosen
This study shows PLK2 loss predicts better response to PLK1 inhibitors in triple-negative breast cancer and suggests PLK2 as a biomarker for treatment response.
bioRxiv · Jun 16, 2021Cancer Biology