Accurate Immune Repertoire Sequencing Reveals Malaria Infection Driven Antibody Lineage Diversification in Young Children
B. S. Wendel, C. He, M. Qu, D. Wu, S. M. Hernandez, K.-Y. Ma, E. W. Liu, J. Xiao, P. D. Crompton, S. K. Pierce, P. Ren, K. Chen, N. Jiang
The paper introduces a high-coverage antibody repertoire sequencing method, MIDCIRS, and uses it to show increased somatic hypermutation in infants and toddlers during malaria infection.
bioRxiv · Jul 9, 2017Immunology