J. Xiao

J chain dictates the recognition of IgA by FcRL4

The paper determines that FcRL4 recognizes IgA via the J chain, revealing structural and functional differences in IgA receptor interactions.

CPT1A Mediates Radiation Sensitivity in Colorectal Cancer

This study identifies CPT1A as a mediator of radiation sensitivity in colorectal cancer, showing its role in ROS scavenging and DNA damage response through the FOXM1-SOD1/SOD2/CAT axis.

FtsZ-mediated spatial-temporal control over septal cell wall synthesis

This paper shows FtsZ treadmilling acts as a template and conveyor to organize cell wall synthesis during bacterial division, with roles changing over time.

Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation

This study identifies GRP7 as a key regulator of ABA-mediated translation efficiency in Arabidopsis by modulating pre-rRNA processing and ribosome distribution.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

CD5L associates with IgM via the J chain

This study identifies CD5L as a component of IgM pentamers, showing it binds to the J chain via a disulfide bond and reduces IgM binding to pIgR.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Coordination of focal adhesion nanostructure and mechano-signaling drives cardiomyocyte differentiation

This study identifies BNIP-2 as a key organizer of focal adhesion nanostructure that enhances signaling and traction force, essential for cardiomyocyte differentiation.

Architecture and activation of human muscle phosphorylase kinase

The paper presents high-resolution cryo-EM structures of human muscle phosphorylase kinase, revealing its architecture and activation mechanism through conformational changes and allosteric regulation.

A methoxylated flavone from Artemisia afra kills Mycobacterium tuberculosis

The paper isolates a methoxylated flavone from Artemisia afra that shows potent anti-Mtb activity against both aerobic and hypoxic Mtb strains.

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease

This paper develops first-in-class PROTAC degraders of SARS-CoV-2 main protease, showing they reduce MPro levels and exhibit anti-SARS-CoV-2 activity.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Spatial and temporal control of lysis by the lambda holin

The paper investigates the molecular basis of polar lysis in phage λ using time lapse fluorescence microscopy, finding that the holin forms two-dimensional rafts at cell poles before lysis.

Insights into RAG evolution from the identification of "missing link" family A RAGL transposons

The paper identifies RAGL-A transposons in invertebrates, showing they share features with both RAG and RAGL-B, suggesting they are a critical intermediate in RAG evolution.

Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

Regional estimates of gross primary production applying the Process-Based Model 3D-CMCC-FEM vs. Remote-Sensing multiple datasets

The paper applies a process-based forest model at 1 km resolution to estimate gross primary production in a Mediterranean region, showing good agreement with remote-sensing data.

Transcriptome mining of RNA viruses (family Totiviridae) in Eimeria necatrix and Eimeria stiedai

The paper identifies and analyzes two new Totiviridae viruses in Eimeria species, revealing phylogenetic insights and suggesting a new genus classification.

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

Propagated circulating tumor cells uncovers the rople of NFκB and COP1 in metastasis

This study develops a CTC and CDX platform to expand patient-derived CTCs and identifies NFκB and COP1 as drivers of metastasis.

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

This study compares kinase activity profiles in human pancreatic beta cells stimulated by GLP-1R agonists with different bias, revealing distinct kinomic responses and potential therapeutic targets.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

TRAF4 is crucial for the propagation of ST2+ memory Th2 cells in IL-33-mediated type 2 airway inflammation

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

Landscape of IGH germline genes of Chiroptera and the pattern of Rhinolophus affinisbat IGH CDR3 repertoire

This study annotates IGH germline genes in three bat species and analyzes the CDR3 repertoire of Rhinolophus affinis, revealing unique immunological features that may explain asymptomatic viral infections in bats.

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

RNAP promoter search and transcription kinetics in live E. coli cells

This study investigates RNAP promoter search and transcription kinetics in live E. coli cells, finding that promoter search is DNA interaction-driven and independent of nucleoid organization, while transcription kinetics is sensitive to cellular conditions.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.